Pletal (Cilostazol)

Pletal reduces attacks of intermittent claudication (pain, cramping, numbness, or weakness in the foot, hip, thigh, or buttocks) that may occur after walking.

Use Pletal as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Pletal by mouth at least 30 minutes before or 2 hours after eating.
• Do not eat grapefruit or drink grapefruit juice while you take Pletal .
• The effects of Pletal are not immediate. Although you may experience the benefits of Pletal 2 to 4 weeks after beginning treatment, treatment for up to 12 weeks may be necessary before Pletal takes effect.

Pletal is a phosphodiesterase type 3 inhibitor. Pletal works by widening arteries that supply blood to the legs and it also decreases the ability of platelets (particles in the blood involved in blood clotting) to stick together.

If you miss a dose of Pletal take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once. If more than one dose is missed, contact your health care provider or pharmacist.

Store at the room temperature away from moisture and sunlight. Keep out of the reach of children.

Do not use Pletal if:

• you are allergic to any ingredient in Pletal;
• you have heart failure.

• Pletal may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Pletal with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Tell your doctor or dentist that you take Pletal before you receive any medical or dental care, emergency care, or surgery.
• Lab tests, including complete blood cell counts, may be performed while you use Pletal . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Pregnancy and breast-feeding: If you are pregnant or become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Pletal while you are pregnant. It is not known if Pletal is found in breast milk. Do not breast-feed while taking Pletal.

Check with your doctor if any of these most common side effects persist or become bothersome:

• abnormal stools; back pain; bloating or swelling of ankles, feet, or hands; diarrhea; dizziness; feeling of a whirling motion; gas; headache; increased cough; indigestion; infection; muscle aches; nausea; runny nose; sore throat; stomach pain; swelling of the legs and feet.

• severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; fast or irregular heartbeat; pounding in the chest; unusual bruising or bleeding; vomiting material that looks like coffee grounds.

This information is a summary only. It does not contain all information about Pletal . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

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 27.01.2008
 Britni
 Redwood City, CA
 I'm very happy using your pharmacy. One of the main things is the quick delivery. It's very important to get the medicine on time, sometimes it's a matter of life and death. You are like an ambulance. Plus I want to mention the quality of your product. All of these make a your business a greate sucess. Thank you very much!

 03.02.2008
 Erick
 Iowa City, IA
 First thing that cought my eye while shopping at your web site was the greate discount on practicly everything. I was a little sceptical abouth the quality of the product at first, but I turned out to be wrong, the quality is great. I also wanted to thank you for saving me a trip to the pharmacy and standing in the line. The delivery was very quick. I'll be glad to use your pharmacy again.

 11.02.2008
 Jenifer
 New York, NY
 Two months ago I found out that my mom has heat problems. We saw a doctor and he prescribed Pletal (Cilostazol), which we got from your pharmacy. A few days of taking Pletal made a big difference. My mom feels much better and is still continiuing the course. Thank you!

 23.02.2008
 Jack
 Blair, NE
 I've been married for 7 years now. We have a great family and we all love each other dearly. A few months earlier I noticed that my sex life i just not the same as it used to be. All of the sudden I wasn't attracted to my wife. It stuck me as a suprize, because i love her very much. Once I spoke about this problem with a friend of mine and it turned out that he went through the same thing. He advised me Pletal. Thanks god they arrive so soon. We are at it again and it feels like the second honey moon. Thank you so much for your products.

 07.03.2008
 Kira
 El Monte, CA
 Starting my teenage years I was suffering from my skin problems. I felt insecure and depressed. I tried alomost everything. Some of the medicines I tried even worsened my condition and led to alergic brake outs. Pletal (Cilostazol) were like a light at the end of the tonnel for me. Gradually but trully the prolem disapeared by itself, I'm very happy and don't even remember how it felt before. All of that thanks to you guys.

 15.04.2008
 Tom
 Cowtown, TX
 3 years ago I broke my leg while skying. It was a spoiled vocation which costed me 6 months of recovery. But I never recovered fully I had severe pains and discomfort feeling, untill I tried your Pletal. I thought I'd never get on the skies again but instead I already booked my next winter vocation at the skying resort for me and my girlfriend.

 21.04.2008
 Christine
 Danvers, MN
 The beauty is the most important posession for woman. But the time does its dirty job. Soom I'm turning 40 and keeping myself in shape requires more and more time and many more hours of work out. The Pletal (Cilostazol) I bought from your pharmacy help me greatly to keep in shape and IT'S OK if I skip the gym once in a while and even more important are the tasty treats that I can afford to have more friquently.

 11.05.2008
 Sean
 Apalachin, NY
 I'm sure I'm not the only victim of irresponsible pharmacies. I think many people would understand my feeling when the medicine arrives so late that you don't need it any more. Your pharmacy has never disappointed me. A broad choice of medicine and great discounts allow me to buy a quality product for a very reasonable price.

 19.05.2008
 Melony
 Chatsworth, CA
 I'm a big pet lover i have two dogs and a cat. I just love watching them run around and play with each other. Recently I noticed that my cat became kind or passive and sleepy and didn't play as much. After a started giving her Pletal (Cilostazol), I bought from your pharmacy, she is back on track again running, jumping and bugging the dogs. Thank you so much for your help.

What is Pletal (cilostazol)?

Cilostazol widens arteries that supply blood to the legs. Cilostazol also improves circulation by keeping platelets in the blood from sticking together and clotting.

Cilostazol is used to treat the symptoms of intermittent claudication. This condition causes reduced blood flow to the legs, leading to pain while walking. Cilostazol improves your ability to walk longer distances without pain.

Cilostazol may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Pletal (cilostazol)?

It may take up to 12 weeks of using cilostazol before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 4 weeks of treatment.

Grapefruit and grapefruit juice may interact with cilostazol. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

What should I discuss with my healthcare provider before taking Pletal (cilostazol)?

Before using cilostazol, tell your doctor if you have:

• heart disease; or

• liver disease.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

How should I take Pletal (cilostazol)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.

It may take up to 12 weeks of using cilostazol before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 4 weeks of treatment.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Overdose symptoms may include a severe headache, diarrhea, feeling light-headed, fainting, and fast or uneven heartbeats.

What should I avoid while taking Pletal (cilostazol)?

Grapefruit and grapefruit juice may interact with cilostazol. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

Pletal (cilostazol) side effects

• severe headache;

• bloody urine, painful urination;

• fever, chills, body aches, flu symptoms;

• chest pain;

• feeling short of breath, even with mild exertion; or

• swelling of your ankles or feet.

Less serious side effects may include:

• fast or pounding heartbeats;

• diarrhea, vomiting;

• weakness, dizziness;

• leg cramps;

• numbness or tingling;

• joint pain; or

• cough, runny or stuffy nose.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect that seems unusual or that is especially bothersome.

What other drugs will affect Pletal (cilostazol)?

Before taking cilostazol, tell your doctor if you are using any of the following drugs:

• clopidogrel (Plavix);

• omeprazole (Prilosec, Zegerid) or esomeprazole (Nexium);

• erythromycin (E.E.S., Ery-Tab, E-Mycin, Erythrocin) or clarithromycin (Biaxin);

• ketoconazole (Nizoral), fluconazole (Diflucan), or itraconazole (Sporanox);

• diltiazem (Cardizem, Tiazac); or

• fluvoxamine (Luvox), fluoxetine (Prozac), sertraline (Zoloft), or nefazodone (Serzone).

This list is not complete and there may be other drugs that can interact with cilostazol. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist has more information about cilostazol.